The effect of psycho-oncological interventions on care burnout in family caregivers of patients with advanced cancer is one of the important issues in comprehensive and family-centered cancer care, as the progression of the disease is usually accompanied by an increase in the physical, psychological, and social needs of the patient, and consequently an increase in pressure on family caregivers. The family caregiver may assume responsibilities such as accompanying the patient, managing medications, coordinating medical visits, assisting with daily activities, emotional support, and communicating with the treatment team over a long period of time, and in this way, he may gradually face physical fatigue, anxiety, sleep disturbances, reduced social activities, economic problems, and feelings of loss of control. Caregiver burnout becomes more important when caregiver pressures exceed the individual's coping capacity and lead to decreased performance, emotional distress, feelings of helplessness, and decreased quality of life. The theoretical foundations of psycho-oncological interventions in this field are based on the bio-psycho-social model, stress and coping theory, family-centered approach, and the concept of self-efficacy, and consider burnout as the result of the interaction between the severity of the patient's needs, the caregiver's psychological resources, social support, andfamily and economic well-being. According to the theory of stress and coping, a difficult situation turns into intense psychological pressure when the person considers it beyond the resources and abilities of the individual. Therefore, the goal of psycho-oncological intervention is not only to reduce caregiver duties, but also to increase the caregiver's psychological resources and coping skills. In the first stage, the psycho-oncologist obtains a comprehensive picture of the caregiver's status by assessing the level of burnout, anxiety, depression, sleep disturbance, guilt, helplessness, caregiver role pressure, and the level of social support. This assessment should be done in accordance with the patient's condition and the advanced stage of the disease and repeated over time, as the caregiver's needs and mental state of the family may change at different stages of the disease. One important intervention is psychological education about the nature of burnout and its causes, as some caregivers see their fatigue and distress as a sign of personal weakness and therefore delay seeking help. The psycho-oncologist can explain to the caregiver that experiencing stress in long-term care settings does not necessarily mean disability, and that paying attention to personal needs is part of sustainable care. The cognitive-behavioral approach also plays a role in correcting dysfunctional beliefs, for example, some caregivers believe that they should meet all of the patient's needs personally, or that resting in a sick situation is considered a form of shortcoming. Rebuilding these beliefs can help reduce feelings of guilt and increase flexibility in sharing responsibilities. Problem-solving skills training also helps caregivers break down complex care problems into smaller, manageable problems and find a specific solution to each problem. Time management, task prioritization, planning for breaks, and using the support of other family members are some of the skills that can reduce caregiver pressure. One of the important goals of the intervention is to strengthen the caregiver's self-efficacy so that the person feels capable of making decisions and taking effective action in the face of everyday problems. Communication skills training also helps the caregiver communicate their needs with the patient, other family members, and the treatment team in a clear way and without feelings of shame or guilt. In many families, the division of caregiver duties is not done properly due to worry, a sense of responsibility, or traditional family patterns, and one person takes over the bulk of care. The psycho-oncologist can provide the ground for a more balanced distribution of responsibilities by facilitating family dialogue. Self-care education is also one of the main components of the intervention and includes attention to sleep, nutrition, physical activity appropriate to the individual's circumstances, social connection, personal time, and relaxing activities. In this context, self-care should not be seen as an activity separate from caring responsibility, but rather as a factor for maintaining the physical and mental capacity of the caregiver. Mindfulness-based interventions can help reduce mental engagement and increase attention to the present moment, while relaxation and breathing techniques can be used to manage arousal and anxiety in stressful situations. In some caregivers, the helplessness caused by observing pain and diminishing the patient's abilities is very pronounced, and the person may feel that they cannot take any action to change the situation. In such a situation, the psycho-oncologist can distinguish between controllable and uncontrollable domains, shifting the caregiver's attention from controlling the outcome of the illness to controlling how they respond and support. Supportive and group interventions can also provide an opportunity to share experiences and receive peer support, reducing caregivers' feelings of loneliness. In advanced cancer, it is also important to pay attention to the semantic and existential dimensions, as the caregiver may be confronted with questions about death, suffering, hope, the future of the family, and the meaning of caregiving. Meaning-based interventions can help the caregiver identify important life values and frame the experience of care in a more meaningful context, without ignoring the reality of the difficulty of the disease. Psycho-oncologist collaboration with the medical, nursing, palliative care and social work team is also important to reduce burnout, as part of the care burden is caused by practical and medical problems and cannot be addressed by psychological intervention alone. Access to palliative care services, symptom control training, social support, and assistance with economic issues can reduce the practical burden of care and increase the effectiveness of psychological interventions. One of the important uses of the intervention is to create ongoing support programs for caregivers rather than providing support solely in times of crisis, as burnout usually develops gradually and early identification allows for the prevention of exacerbations. The use of periodic assessments can identify changes in caregiver burden, emotional distress, and quality of life. Telepsychological services can also be a good complementary option for caregivers who are unable to attend in person due to constant presence with the patient. However, challenges such as limited access to specialized services, economic difficulties, lack of time, extreme fatigue, and negative attitudes toward receiving psychological help may reduce caregiver engagement. Some caregivers may also ignore their psychological needs due to their complete focus on the patient and do not seek help until they reach the extreme stages of burnout. Cultural and family differences can also affect how they receive help, divide tasks, and express emotions. One of the limitations of psycho-oncological interventions is that it is not possible to control all the factors that cause burnout through psychological treatment; the severity of the disease, economic status, the degree of dependence of the patient, the length of care, the quality of social support are factors that are outside the direct control of the psycho-oncologist. Also, not all caregivers benefit equally from the same type of intervention, and it is necessary to adjust the treatment plan based on individual needs, the caregiver-patient relationship, the severity of burnout, and the stage of the disease. In cases where the caregiver suffers from severe depression, severe anxiety, significant dysfunction, or traumatic thoughts, a more specialized assessment and referral to a psychiatrist is necessary. It is suggested that psycho-oncological services be made available to the family in a phased and continuous manner from the beginning of the diagnosis of the advanced disease, and that the evaluation of the caregivers be carried out alongside the patient's evaluation. Creating educational programs for the family, caregiver support groups, couples and family sessions, training in coping and communication skills, and regular linking with palliative care services can provide a comprehensive framework for reducing burnout. Ultimately, the goal of psycho-oncological interventions is not to completely eliminate caregiver stress, but rather to help the caregiver manage stress, maintain mental and physical health, use supportive resources, share responsibilities, and continue care without completely losing their quality of life. Simultaneously paying attention to the patient and caregiver can transform advanced cancer care into a more humane and sustainable process and address the caregiver's mental health status as an integral part of comprehensive cancer care.