The effect of psycho-oncological interventions on reducing the psychological distress of family members of cancer patients can be examined in a multidimensional framework in which the family is considered not only as the patient's companion, but also as part of the care system and one of the main recipients of the psychological consequences of the disease. A cancer diagnosis can create a critical experience for family members and is associated with increased anxiety, depression, worry about the future, fear of death, feelings of powerlessness, sleep disturbances, caregiver burnout, and decreased quality of life. The severity of this distress depends on the stage of the disease, type of treatment, prognosis, level of dependence on the patient, the role of the primary caregiver, economic status, and family support resources. Psycho-oncological interventions are designed to identify, prevent, and reduce these psychological stresses and can continue from diagnosis to treatment, rehabilitation, the likelihood of relapse, palliative care, and bereavement. The first stage of the intervention is screening and assessing psychological distress to identify family members who are at risk of significant anxiety or depression. By assessing emotions, thoughts, behaviors, family relationships, and social conditions, the psycho-oncologist can identify the aggravating factors of distress and adjust the intervention plan according to the needs of each family. One of the important mechanisms to reduce distress is to increase awareness and psychological education, as ignorance about the disease and treatment can lead to catastrophic perceptions and constant worry. Education about the treatment process, natural psychological reactions, coping with complications, and methods of patient support can increase the sense of control and predictability. Cognitive-behavioral interventions can also help reduce some symptoms of anxiety and depression by focusing on negative thoughts, extreme worries, guilt, and catastrophic predictions. In this approach, family members learn to identify automatic thoughts associated with illness and differentiate between medical realities and anxious perceptions. Problem-solving skills training is also important, as the family faces multiple decisions about care, commuting, financial issues, division of duties, and emotional support during treatment. Turning complex problems into manageable issues can reduce feelings of helplessness. Emotion regulation is also an essential focus of psychooncological interventions, as the constant suppression of fear, anger, and sadness may lead to increased psychological stress. Family members can better manage their reactions by learning skills such as relaxation breathing, mindfulness, cognitive restructuring, and emotion acceptance. Interventions based on acceptance and commitment also try to help the family maintain valuable life activities while accepting the difficult reality of illness and not affecting their entire mental life with cancer. Social support is another contributing factor to distress, and the psycho-oncologist can encourage the family to identify and use the support resources available in the family, social, and therapeutic network. In primary caregivers, self-care education is particularly important, as a caregiver who neglects all of their physical and psychological needs may experience burnout, fatigue, and a reduced ability to care. Support programs can include breaktime, sharing responsibilities, and maintaining personal activities as part of professional care. Family interventions can also improve the quality of communication between the patient and family members, as many conflicts stem from differences in the way they deal with the disease. One member may be inclined to talk about cancer, while the other member may avoid the conversation, and this difference sometimes leads to misunderstandings and increased distress. By teaching empathetic communication, active listening, and clear expression of needs, a psycho-oncology can provide a context for more constructive interaction. In families where children are also involved in the consequences of a parent's illness, interventions should be tailored to the child's age and cognitive level to reduce anxiety caused by ambiguity and secrecy. On the other hand, in the families of patients with advanced cancer, the focus of interventions can be on managing fear, maintaining connection, meaning, psychological readiness, and alleviating the suffering of family members. Research evidence in the field of cancer psychology has shown that psychological interventions can help reduce distress, anxiety, and depression and increase adaptation in some family groups, but the level of effectiveness depends on the type of intervention, duration of treatment, family characteristics, and initial severity of distress. Some studies also suggest that group interventions can provide the opportunity to exchange experiences and receive social support in addition to reducing loneliness. Individual counseling may be more appropriate for members with more severe distress, while families with communication conflict can benefit from family-centered or couple-centered interventions. The use of digital interventions and telepsycho-oncology can also increase the accessibility of families who are unable to attend treatment facilities regularly due to geographical distance, time constraints, or care conditions. However, access to technology, digital literacy, and privacy are factors that need to be considered. Art and narrative-based therapy can also be used as complementary interventions to express emotion, reconstruct the experience of illness, and create an opportunity for dialogue in the family, especially when it is difficult to express emotions directly. Despite the capacity of these interventions, reducing psychological distress cannot be achieved with just one session or one technique and requires continuous evaluation and adaptation of the intervention to the stage of the illness. One of the major challenges is that some family members do not consider themselves sick and do not consider it necessary to go for psychological services. Social stigma associated with psychological services, shortage of psycho-oncology specialists, cost of treatment, care pressure, and time constraints can also hinder family participation. Also, the severity of the illness may change rapidly and change the psychological needs of the family, so the intervention plan should be flexible. In some families, too, a strong focus on patient support may marginalize the caregiver's psychological needs and his/her distress may remain hidden until the advanced stages. Therefore, the primary caregiver's assessment should be part of psychological cancer care. The goal of psycho-oncological interventions is not simply to eliminate negative emotions entirely, as fear, sadness, and worry in the face of cancer can be normal reactions; the main goal is to prevent these reactions from turning into persistent and debilitating distress and to increase the family's ability to adapt, make decisions, communicate effectively, and maintain quality of life throughout the course of the disease.