The quality of life of caregivers of patients with cancer is one of the important components of comprehensive cancer care, because long-term care of the patient can affect the physical, psychological, social, economic, and spiritual dimensions of the caregiver's life, and in the absence of appropriate support, provide the ground for reduced performance and care burnout. Family-centered psycho-oncological interventions are formed with the basic assumption that the experience of cancer does not remain within the patient's limits, but the family and especially the primary caregiver are also part of the disease process and treatment, and their needs should be considered in the care plan. From the perspective of the psychosocial and spiritual model, quality of life is the result of the interaction of physical condition, mental health, social relationships, environmental conditions, and semantic resources, so improving the caregiver's quality of life requires a multidimensional intervention that does not focus solely on reducing a psychological symptom. Family systems theory also emphasizes the interdependence of family members and shows that the psychological or physical stress of one member can affect the performance of other members. Accordingly, in addition to supporting the caregiver, family-centered intervention tries to strengthen communication patterns, division of responsibilities, and supportive resources of the family. In the first stage, the psycho-oncologist identifies the individual's specific needs by assessing the caregiver's quality of life, level of anxiety and depression, fatigue, sleep disturbances, caring burden, social functioning, economic status, family support, and coping strategies. This assessment should be repeated at different stages of the disease, as the caregiver's quality of life may change significantly at the time of diagnosis, active treatment, hospitalization, relapse, and palliative care. One of the main goals of family-centered interventions is to reduce psychological distress, as anxiety and depression can reduce the caregiver's mental energy and disrupt daily functioning, social relationships, and a sense of life satisfaction. Cognitive-behavioral interventions can help reduce distress by identifying catastrophic thoughts, correcting dysfunctional beliefs, teaching problem-solving, and reinforcing adaptive behaviors. For example, a caregiver who takes full responsibility for the patient's situation or feels they need to care for the patient without a break may experience more burnout, and rebuilding these beliefs can help strike a balance between patient care and self-care. Emotion regulation, relaxation, and mindfulness training can also help caregivers manage ongoing worries, intrusive thoughts, and emotional arousal. On the other hand, behavioral activation can encourage the caregiver to gradually return to social, occupational, and enjoyable activities, as limiting life entirely to patient care may reduce quality of life over time. An essential component of family-centered intervention is to modify the division of caregiving responsibilities. When all tasks are placed on the shoulders of a caregiver, the likelihood of fatigue, stress, and limitations of personal activities increases, so a psycho-oncologist can help members identify their capacities and limitations and distribute responsibilities more realistically. Improving family relationships is also an important pathway to improving the caregiver's quality of life, as conflict, misunderstandings, and a lack of emotional support can increase the psychological burden of caregiving. Communication interventions help family members articulate their needs clearly, agree on caregiving tasks, and distance themselves from patterns of blame or prolonged silence. Caregiver education about the illness and the treatment process can also reduce feelings of ambiguity and powerlessness and increase their self-efficacy, although this training should be tailored to verified medical information and coordinated with the treatment team. Increasing self-efficacy is important, as a caregiver who overestimates his or her ability to manage the patient's needs may experience more manageable situational pressure. Problem-solving interventions help the caregiver break down complex problems into smaller steps, set priorities, and plan for predictable situations. Social support is also an important part of the caregiver's quality of life, and the psycho-oncologist can identify and activate formal and informal sources of support. Caregiver support groups, family and friends network, social work, and community-based services can alleviate some of the practical and emotional strain of care. In families with limited social resources, referrals to a social worker are particularly important to explore available supports, social services, and economic issues. In cases where the illness is prolonged or advanced, meaning-based and existential interventions can also play a role in maintaining the caregiver's quality of life, as the experience of care may raise questions about the meaning of suffering, responsibility, hope, loss, and the future. A meaning-centered approach attempts to help the caregiver identify their personal and family values and not limit life to a mere caring role. In palliative care settings, psychological support can focus on tolerating uncertainty, processing grief in advance, connecting with the patient, and maintaining emotional presence. In such a situation, quality of life does not necessarily mean the absence of sadness or anxiety, but rather it means maintaining connection, dignity, choice, and valuable activities alongside accepting the reality of the disease. Family-centred interventions can also reduce conflicts associated with treatment and care by strengthening communication and participatory decision-making skills, and prevent the transmission of stress between family members. The use of group interventions and telepsycho-oncology can also increase caregivers' access to specialist services, especially when responsibility for care limits the possibility of frequent visits to treatment facilities. However, digital interventions should be used with regard to information confidentiality, communication security, digital literacy, and the quality of the therapeutic relationship. An important limitation in this area is the heterogeneity of families in terms of structure, culture, financial resources, type of cancer, stage of disease, degree of patient dependence, and social support network, so the effectiveness of an intervention may vary from family to family. Another limitation is that some health care facilities focus on the patient's quality of life and inadequate evaluation of the caregiver, while a decrease in the caregiver's quality of life can also affect their ability to continue care. Also, some caregivers hide their needs due to a sense of duty, social stigma, or fear of the judgment of others, and may not seek psychological help. It is suggested that quality of life assessment and burden of care be included periodically in the cancer care plan and that at-risk caregivers be referred to psycho-oncological services. Designing phase-based family-centered programs that begin at diagnosis and continue throughout treatment, survivorship, relapse, and palliative care can increase the continuity of support. It is also recommended that interventions be designed as a combination of psychological education, emotion regulation, cognitive-behavioural, problem-solving, family therapy, social support, and self-care to address different dimensions of quality of life. Psycho-oncologist collaboration with oncologist, nurse, social worker, psychiatrist, and palliative medicine specialist is also essential to create integrated care. Overall, psycho-oncological family-centered interventions can improve the quality of life of caregivers of cancer patients by simultaneously targeting psychological distress, caregiver burden, relationship quality, self-efficacy, and social support. The importance of these interventions lies in the fact that they do not consider the caregiver merely as a person who has to perform caregiving tasks, but rather as a person with physical, emotional, social, and meaningful needs whose health and quality of life are part of comprehensive cancer care. The ultimate goal of such an approach is to strike a balance between patient care and the maintenance of the caregiver's life, a balance that can prevent burnout, increase family coping capacity, and allow for the continuation of effective and sustained care in the complex course of cancer. to continue.