The family care burden of cancer patients is one of the most important psychological and social consequences of the disease, which is formed as a result of the interaction between the patient's physical needs, treatment requirements, daily responsibilities, emotional pressures, economic constraints, and changing family roles, and can affect the quality of life of the patient and caregiver at the same time. In many cases, caring for a patient with cancer is a long and multi-stage process that begins at the time of diagnosis and may continue during surgery, chemotherapy, radiation therapy, systemic therapies, survival, recurrence, or palliative care. The care burden is not limited to the number of tasks performed for the patient, but also has several objective and subjective dimensions and includes time spent on care, fatigue, sleep disturbances, financial pressure, limitation of social activities, change in family roles, worry about the future, and a constant sense of responsibility for the patient's situation. From the perspective of the theoretical foundations of psycho-oncology, the caregiver burden should be examined within the framework of the psychosocial and spiritual biomodel, as its severity is affected by the patient's physical condition, the caregiver's psychological characteristics, the quality of family relationships, social resources, economic conditions, and the individual's belief system. Family systems theory also considers the family as an interconnected unit in which changing the status of one member can alter the balance of the entire system, so cancer may change the division of roles, communication patterns, economic responsibilities, and family decision-making styles, increasing the caring burden on one or more members. Psycho-oncological interventions aimed at reducing this burden first carefully assess the caregiver and family's conditions and examine the level of physical stress, psychological distress, anxiety, depression, burnout, sleep quality, social support, and coping capacity. The assessment of the caregiver burden should be repeated at different stages of the disease, as the patient's care needs are not constant and may increase during periods such as initiation of treatment, hospitalization, the occurrence of complications, or the recurrence of the disease. One of the most important mechanisms to reduce the caregiver burden is to increase the caregiver's sense of self-efficacy, because the person who is more skilled and confident in managing caregiving tasks usually assesses the situation as more manageable and the likelihood of experiencing helplessness is reduced. The psycho-oncologist can strengthen the caregiver's ability to face the patient's needs by teaching problem-solving skills, care planning, setting priorities, and emotion management. Accurate and tailored education about the treatment process can also reduce ambiguity and anxiety caused by ignorance, although this training should be coordinated with the patient's medical plan and should avoid providing contradictory or out-of-the-box information. Another essential component of the intervention is helping the family to share responsibilities rationally, as focusing all tasks on a primary caregiver can lead to physical and psychological exhaustion. A psycho-oncologist in family sessions can guide members to identify each other's abilities and limitations, divide tasks, and create a flexible care plan. This process is especially important in families where a family member has assumed primary responsibility for care due to cultural beliefs, gender roles, or a strong sense of commitment. Cognitive-behavioral interventions can also be effective in reducing the mental burden of caregiving, as some caregivers are faced with catastrophic thoughts, feelings of guilt, excessive responsibility, or a belief in the necessity of complete and uninterrupted care. Cognitive restructuring can help the caregiver differentiate between actual and perceived responsibility and moderate unrealistic standards about complete care. Training in emotion regulation, relaxation, and mindfulness skills can also reduce the intensity of the caregiver's emotional reactions in stressful situations and increase the caregiver's capacity for flexible response. An important aspect of the intervention is attention to self-care, as some caregivers think that devoting time to personal needs is a form of neglect of the patient, while caregiver burnout can also reduce the ability to provide appropriate care in the long term. By teaching the concept of sustainable care, a psycho-oncologist can encourage the caregiver to maintain sleep, proper nutrition, appropriate physical activity, social connection, personal activities, and rest time. In this context, the goal is to strike a balance between patient care and the maintenance of the caregiver's physical and mental resources. Social support is also an important factor in moderating the caregiver's burden, and psycho-oncological interventions can lead the family to use formal and informal support networks. Seeking help from other family members, friends, support groups, social workers, and social services can take some of the responsibilities off the shoulders of the primary caregiver and reduce feelings of loneliness and absolute responsibility. Caregiver support groups can also increase the perception of social support by providing a space for the exchange of experiences, education, and empathy. In families where conflict between members has increased caregiver pressure, family therapy and communication interventions can focus on modifying communication patterns, reducing blame, increasing empathy, and creating agreement about caregiver tasks. Sometimes the burden of care arises not only from the severity of the patient's needs, but also from the weakness of communication between family members, and in such a situation, communication modification can be one of the important ways to reduce stress. In the advanced stages of the disease, meaning-based and existential interventions can also help the family redefine the experience of care within the framework of meaningful values and relationships, and cope with feelings of guilt, lack of control, and fear of death more adaptively. In palliative care, the psycho-oncologist can prevent the increased psychological burden caused by complex situations by supporting the family in making decisions, communicating about care goals, tolerating uncertainty, and processing difficult emotions. Digital interventions and telepsycho-oncology can also increase access to psychological services for caregivers who do not have the opportunity to visit in person due to many responsibilities and provide the possibility of continuous follow-up, however, the use of these methods should be done according to the confidentiality of information, digital literacy, and the quality of the therapeutic relationship. One of the important limitations in reducing the burden of care is the wide differences between families in terms of structure, economic resources, culture, type of cancer, stage of the disease, severity of patient dependence, and social support network, so a single program cannot be suitable for all families. Another limitation is the difficulty of identifying a hidden care burden, as some caregivers do not report their fatigue and stress due to a sense of responsibility or concern about the judgment of others. Also, in many health systems, the main focus is on the patient's medical indicators and the caregiver's needs are not evaluated on a regular basis. It is suggested that the assessment of the care burden become a fixed component of comprehensive cancer care and be reviewed periodically at critical points in the treatment path. Designing stage-based psycho-oncological protocols, caring skills training, cognitive-behavioral interventions, emotion regulation training, task division planning, social support, and family interventions can make the burden of care more targeted. Close collaboration of the psycho-oncologist with the oncologist, nurse, social worker, palliative medicine specialist, and other members of the treatment team is also essential to address the needs of the patient and the family in an integrated manner. It is also better to design intervention programs in such a way that in addition to reducing the current pressure, they also develop sustainable coping skills in the family. Overall, psycho-oncological interventions can help reduce the burden of caring for the families of cancer patients by increasing self-efficacy, reducing psychological distress, correcting dysfunctional thoughts, strengthening emotion regulation, improving family communication, more equitable distribution of responsibilities, and increasing social support. The ultimate goal of these interventions is not to eliminate caring responsibility, but to transform exhaustive and one-on-one care into an organized, participatory, flexible, and supportive process so that the family can meet the needs of the patient, while also maintaining its psychological, physical, and social resources, and preventing burnout and lasting disruption in family functioning along the course of the disease.