Psychosomatic art therapy in psycho-oncology is an integrated approach that examines the experience of cancer in the link between physical symptoms, emotion, cognition, behavior, social relationships, and personal meaning of the disease, and employs art as a complementary intervention to support the patient's psychological and physical adjustment. Cancer and related therapies can cause a series of physical symptoms such as pain, fatigue, nausea, sleep disturbances, and body image changes, as well as anxiety, depression, fear of relapse, distress, and feelings of lack of control. The psychosomatic approach considers these symptoms not as completely separate phenomena, but in the form of interactions between physical and psychological processes, without considering physical symptoms as merely psychological factors. In this framework, art therapy can make it possible for the patient to express experiences that are difficult or even impossible for the patient to explain in verbal language alone, through painting, drawing, collage, music, creative writing, and other artistic activities. Visual representations of pain, fatigue, fear, body changes, or the experience of therapy can help the patient organize their emotions and perceptions and become more aware of the relationship between them. One of the important theoretical foundations of this approach is emotion regulation; artistic activity can help identify, name, tolerate, and moderate unpleasant emotions, and increase the possibility of observing the difficult experience by creating psychological distance. When a patient represents their anxiety or fear in the form of images, colors, or narratives, the emotional experience is completely internalized and ambiguous and becomes a visible and conversationable topic. This process may foster a sense of control and agency, especially in situations where illness and medical treatment have reduced an important part of a person's control over the body and daily routine. Artistic activity can also shift the patient's attention from rumination and a constant focus on threat to a purposeful and creative process, reducing distress and increasing relaxation in some people. From a psychophysiological perspective, a decrease in emotional arousal may be associated with changes in some stress-related responses and autonomic nervous system activity, but such changes should be considered as possible mechanisms, and attributing them directly to art therapy requires rigorous empirical evidence. The available evidence in the field of art interventions for patients with cancer has been reported in some studies to reduce anxiety, depression, and psychological distress and improve some aspects of quality of life, but the extent and persistence of these effects are not the same in different studies, and differences in the type of cancer, stage of the disease, treatment method, type of artistic activity, and individual characteristics can affect the results. In psycho-oncology, art therapy can be used from diagnosis to active treatment, rehabilitation, survival, and palliative care, and has a different goal at each stage. At the time of diagnosis, the focus can be on reducing shock and anxiety, creating a sense of security, and facilitating the expression of emotion; during treatment, distress management, adaptation to physical complications, and maintaining patient participation become more important, and in the post-treatment period, rebuilding identity, body image, and meaning of life can be at the center of the intervention. In palliative care, art can also provide the possibility of expressing fear, grief, important relationships, memories, and semantic issues, and help to support the patient's psychological and social support. One of the important applications of the psychosomatic approach is the complementary management of pain. Cancer pain is influenced by physical, emotional, and cognitive factors, and art therapy can make the experience of pain more bearable for some patients by directing attention, reducing tension, increasing the sense of control, and providing the possibility of expressing emotions associated with pain. Cancer-related fatigue can also be influenced by physical and psychological factors, and artistic activities tailored to the patient's physical ability may help reduce passivity, strengthen participation, and create a positive experience, although the choice of activity should be coordinated with the patient's energy status and medical condition. Changing body image after surgery or treatment is also one of the important areas of application of this approach, and art can provide the possibility of recognizing the changed body and rebuilding the person's relationship with their physical appearance and identity. In this process, the work of art should not be interpreted as a diagnostic test or a set of symbols with a fixed meaning; the meaning should be extracted from the patient's own narrative and the therapeutic dialogue. Important challenges in this area include the heterogeneity of art therapy protocols, differences in the number of sessions and media used, limited sample size in some researches, and difficulty in separating the specific effect of art therapy from the effect of relationship therapy and social support. Also, the physical condition of patients with cancer may change rapidly, and therefore the intervention should be flexible and appropriate to the stage of the disease, the complications of the treatment, and the psychological and physical capacity of the individual. Collaboration between the psycho-onclogist, art therapist, psychologist, physician, nurse, and other members of the treatment team is important for a comprehensive assessment and realistic goal setting. It is suggested that the level of distress, anxiety, depression, pain, fatigue, sleep quality, body image, quality of life, and the communication needs of the patient be evaluated before initiating the intervention, and artistic activity should be selected based on this assessment. Future research should also use clear protocols, appropriate control groups, larger samples, long-term follow-up, and validated psychological and physical measures to determine which components of art therapy are most beneficial for which patients and at what stage of cancer. Psychosomatic art therapy in psycho-oncology can provide an integrated framework for simultaneously paying attention to the psychological and physical experience of cancer and help the patient to adapt to the disease process and treatment through emotion regulation, non-verbal expression, increasing self-awareness, strengthening the sense of control, body image reconstruction, meaning-making, and social support.