Psychosomatic art therapy in the framework of brain-body communication is an interdisciplinary approach that considers the creative process as a platform for the interaction between emotion, cognition, bodily perception, and physiological responses, and is based on the principle that psychological experience and physical status in humans are not separate from each other. In situations of stress, anxiety, pain, or chronic illness, increased emotional arousal can be accompanied by changes in the activity of the autonomic nervous system, breathing patterns, heart rate, muscle tension, and the hypothalamic-pituitary-adrenal axis, and in contrast, physical symptoms can also lead to increased worry and emotional sensitivity. Art therapy provides the possibility of modulating part of this cycle by creating a purposeful and creative activity, through the regulation of attention, the expression of emotion, increased self-awareness, and the creation of a sense of control. In this process, painting, drawing, music, collage, sculpture, and creative writing do not merely create an artistic product, but can also act as media for observing and organizing the inner experience. When creating a work, the individual shifts part of his attention from threatening stimuli and recurring thoughts to the process of selection, composition, movement, and construction, and this shift of attention may reduce the intensity of the conflict with rumination and emotional arousal. One of the important theoretical foundations in this field is the concept of emotion regulation, because the creative process allows the individual to identify, tolerate, symbolize, and reconstruct emotion in a visible format. When an experience such as fear, anger, pain, or helplessness is expressed in the form of images or sound, the individual can better see the relationship between their emotional state and their bodily sensation and move from automatic reaction to more conscious processing. From a neuropsychological perspective, creative experience can involve networks related to attention, emotion processing, motivation, and self-referential processing, but attributing specific brain changes to art therapy requires direct and controlled evidence and cannot be used as proof of a single mechanism. Some studies on artistic and music-based interventions have reported reductions in anxiety and distress and changes in some stress-related physiological indicators, but the results of the studies differ in terms of the type of intervention, the population studied, and measurement indices. At the psychophysiological level, a decrease in tension and an increase in relaxation may be associated with a change in the balance of sympathetic and parasympathetic activity, and in some situations changes in heart rate or other indicators related to the stress response, but these changes should be considered as possible and condition-dependent outcomes. Psychosomatic art therapy can also increase physical self-awareness; when a person pays attention to color, movement, rhythm, hand pressure, or posture, a person can communicate more accurately with their physical sensations and better recognize the difference between pain, tension, anxiety, and other bodily sensations. This feature is especially important in patients with chronic diseases, as the constant experience of physical symptoms may create a cycle of excessive attention to the body, worry, and increased arousal. Artistic activity can help change the way you deal with it in such a situation, rather than eliminating the symptom. In patients with cancer, for example, art therapy can help process fear of illness, treatment anxiety, body image changes, and distress caused by physical symptoms, and in addition to medical care, the creative process can affect the experience of pain through shifting attention, reducing tension, and increasing the sense of agency, but it should not be considered as a substitute for treating the physical cause of pain. Another possible mechanism is to increase the sense of control, as illness and medical treatment sometimes reduce a person's sense of authority, while the process of creation allows for the free choice of color, shape, sound, and structure. This experience can be effective in restoring a sense of agency and fostering psychological adjustment. On the other hand, creativity can provide a context for meaning-making and enable a person to reconstruct the experience of illness or physical crisis in the form of a personal narrative. Such a process may create greater psychological cohesion and help reduce the turmoil caused by scattered experiences. Clinical applications of this approach can include reducing psychological distress, aiding in emotion regulation, supplemental pain management, reducing anxiety, improving adaptation to chronic illness, supporting quality of life, and strengthening therapeutic communication. Despite these capacities, the main challenge in this area is the complexity of the relationship between creativity and physiological responses, as body changes are influenced by several factors such as medications, underlying disease, sleep, nutrition, therapeutic environment, and individual characteristics. Also, not every physical change after artistic activity can be directly attributed to the psychological mechanism. Another limitation is the large differences in art therapy protocols and the lack of a uniform standard for the duration, intensity, and type of creative activities. Future research can investigate the possible mechanisms of these interventions more accurately by simultaneously using psychological measures and more objective psychophysiological indicators, such as heart rate variability, stress-related indicators, and behavioral measures. Designing controlled studies, larger samples, long-term follow-up, and separating the effect of the type of artistic media from the therapeutic relationship effect are also necessary to increase the scientific credibility of this field. In general, psychosomatic art therapy can be considered as a complementary approach that provides the possibility of simultaneous intervention in the psychological and physical dimensions of human experience through creativity, attention regulation, emotion processing, bodily self-awareness, meaning-making, and strengthening the sense of control.