The role of psychosomatic art therapy in patients with cancer is based on the assumption that the experience of cancer is the result of a complex interaction between physical status, emotion, cognition, behavior, and social conditions, and therefore psychological intervention should also address these dimensions in an integrated manner. Cancer diagnosis, therapeutic processes, changes in body appearance, pain, fatigue, functional limitations, and worry about the future can increase anxiety, depression, fear, anger, feelings of helplessness, and psychological distress, and in some patients, decrease the ability to regulate emotion. Psychosomatic art therapy allows for the representation of emotions and physical experiences associated with illness by providing a non-verbal, experience-based platform, allowing the patient to organize and express their complex emotions through painting, drawing, collage, music, creative writing, or other artistic media. Theoretically, this process can help regulate emotion by increasing emotional awareness, reducing avoidance, facilitating the processing of difficult experiences, and fostering a sense of control over the experience of illness. When a patient represents experiences such as fear of progressing the disease, fear of complications of treatment, or a change in body image, his inner experience is removed from a vague and scattered state and becomes a visible and discussible topic. This process can create a proper psychological distance between the person and the emotion, increasing the possibility of observing and processing it without being completely immersed in the emotional experience. Artistic activity can also reduce the intensity of constant focus on threatening symptoms and anxious thoughts by directing attention to the mood process, and enhance the feeling of being present in the moment. At the psychosomatic level, decreased arousal and increased relaxation may be associated with changes in stress-related responses and regulation of autonomic nervous system activity, although these mechanisms should not be considered as a definitive and direct relationship between art therapy and biological changes. Research evidence in the field of art interventions in oncology has shown that such interventions in some patient groups can be associated with a reduction in anxiety, depression, and psychological distress and an improvement in some dimensions of quality of life, but the rate of effectiveness varies in different studies and depends on factors such as type of cancer, stage of disease, type of treatment, individual characteristics, and structure of the intervention. The application of this approach can extend from diagnosis and initiation of treatment to chemotherapy, radiation therapy, surgery, rehabilitation, and supportive care, focusing on a different psychological need at each stage. In the course of chemotherapy, artistic activity can be used to reduce anxiety before treatment, process the emotions caused by physical complications, and increase the patient's sense of involvement, and in the post-treatment period, it can also help to reconstruct identity, body image, and a sense of continuity of life. In patients with advanced cancer, art therapy can provide a space to express fear, grief, worry about the future, and search for meaning, and help with psychological support along with palliative care. One of its important applications in the management of psychological distress is to make it possible to communicate between emotions and physical experiences, for example, the patient can show the location and quality of the sensation of pressure, pain, or tension in the form of color and shape, and then discuss the emotions that accompany it. This method does not mean that the source of pain or other physical symptoms is psychological, but rather allows for a better understanding of the multidimensional experience of the disease. Art therapy can also play a role in strengthening the sense of agency, as the patient has choice, decision-making, and control in the process of creating the work, which in the context of cancer may have been reduced by dependence on the therapeutic system and the experience of medical interventions. Creating a work of art can create an experience of choice and success, thereby helping to rebuild a sense of empowerment. At the same time, the clinical use of art therapy requires careful assessment of the patient's level of distress, cognitive and emotional state, communication ability, and physical condition, and should not be a substitute for medical treatment or evidence-based psychotherapies. Limitations include heterogeneity in research protocols, differences in artistic media, number of sessions, sample sizes, and measurement tools, which limit the generalization of results. It is also unclear how much of the observed changes are due to the artistic activity itself, relationship therapy, social support, or regular attendance at an intervention program. Therefore, it is suggested that future interventions be designed based on an individual psycho-oncological assessment and that outcomes such as anxiety, depression, distress, emotion regulation, quality of life, and perception of control be examined on a regular basis. The use of standard protocols, controlled studies, longer follow-ups, and collaboration between the psychologist, psycho-oncology, art therapist, physician, and other members of the treatment team can help clarify the effectiveness and mechanisms of this approach. In general, psychosomatic art therapy can play a role in reducing psychological distress and promoting the adaptation of patients with cancer through emotion expression and processing, increasing self-awareness, reducing avoidance, strengthening the sense of control, and creating a connection between psychological and physical experience.