Psychosomatic art therapy is an interdisciplinary approach in which the interplay of psychological, emotional, neurological, and physical processes in the experience of illness and health is considered, and art is used as a medium to modulate these interactions. The theoretical basis of this approach is based on the mind-body perspective, according to which emotions, thoughts, stress, and psychological experiences can affect physical status through neurological, hormonal, and automatic pathways, while physical symptoms and changes can affect emotion, cognition, and behavior. In this context, therapeutic artis not merely an activity for entertainment or emotional discharge, but can be used as a complementary psychological intervention to identify, organize, and regulate emotional and physical experiences. Processes such as painting, collage, illustration, music, creative writing, and working with art materials allow experiences that are difficult to verbally express in a symbolic and visible way. This representation can help a person better recognize the connection between their feelings, thoughts, memories, and bodily sensations, and to transform the experience of illness from a vague and scattered state into a more comprehensible one. From a psychophysiological perspective, a decrease in emotional arousal and an increased sense of control may be associated with a modulation of autonomic nervous system activity and a decrease in stress-related responses. Also, focusing on artistic activity can create a kind of attention regulation and distance the individual from the constant cycle of worry, rumination, and monitoring of physical threats. In some theoretical models, this process is explained by increasing physical self-awareness, emotion regulation, and strengthening the sense of agency. Research evidence in the field of art therapy and physical diseases has shown that art interventions can be associated with a reduction in anxiety, depression, psychological distress, pain perception, and emotional stress in some populations, as well as an improvement in some indicators of quality of life. In studies related to chronic diseases and cancer, art therapy has been investigated as a complementary intervention to support psychological adjustment, expression of emotion, and reduce the psychological burden of treatment. However, the intensity and persistence of these effects are not the same in different studies, and differences in the type of intervention, duration of treatment, sample characteristics, and evaluation tools have made the results of the studies not completely homogeneous. The psychosomatic application of art therapy can be considered in the management of pain, fatigue, anxiety, sleep disturbances, stress caused by chronic diseases, adjustment problems, and distress associated with medical procedures. In this process, the art therapist or psychologist must make a professional distinction between emotional experience and the somatic symptom and avoid directly attributing any physical symptoms to psychological factors. This principle is particularly important, as physical symptoms may be of medical, pharmacological, neurological, inflammatory, or multifactorial origin, and art therapy is not a substitute for medical diagnosis and treatment. In clinical work, the initial assessment can include an examination of emotional status, stress patterns, quality of life, pain experience, body image, coping styles, social support resources, and relevant medical history. Then, based on the individual's needs, the appropriate artistic activity is selected, and the process of creating the artwork proceeds along with therapeutic dialogue and reflection of the physical and emotional experience. For example, a person with a chronic illness can represent their body changes, feelings of pain, or concerns in the form of an image, and then discuss the feelings and meanings associated with the work. In pain management, artistic activity may affect the experience of pain by directing attention, reducing tension, increasing active participation, and creating a sense of control, although it should not be considered as a direct treatment of the cause of pain. In the field of medical anxiety, artistic activity can help create a sense of security, predictability, and participation before certain therapeutic actions. In chronic diseases, art can also provide a space for rebuilding a person's identity, as illness sometimes changes a person's image of their body, their future, and their social roles. Another important application of this approach is to enhance emotion regulation, which allows a person to better observe and organize the intensity and quality of their emotion through the choice of color, form, movement, sound, or artistic narrative. From a psychosomatic perspective, the main goal is to create a healthier connection between subjective perceptions and bodily experiences, rather than eliminating unpleasant emotions or denying physical symptoms. Art therapy can also help in group interventions to strengthen social support, reduce feelings of isolation, and increase the sense of belonging, and these factors are indirectly related to better adaptation to illness. Despite the capacities of this approach, one of its main challenges is the difference in the quality and structure of art therapy protocols, and the lack of a single standard in the type of activity, number of sessions, and method of assessment makes it difficult to compare the results of studies. Another limitation is the difficulty of separating the specific work of art therapy from the effect of relationship therapy, professional attention, social support, and participation in a regular treatment program. Also, some people may resist artistic activity or consider themselves lacking artistic ability, so the intervention should focus on the process of experience and meaning, not on the aesthetic quality of the product. On the other hand, the misuse of the interpretation of symbols can lead to invalid or traumatic perceptions, and for this reason, the interpretation of the artwork should be participatory and based on the meaning that the client himself attributes to the work. For the scientific development of this field, it is necessary to design studies with larger samples, appropriate control groups, long-term follow-up, and standard psychological and physical indicators. The simultaneous use of self-report measures, behavioral indicators, and, if possible, some physiological indicators can provide a more accurate assessment of possible mechanisms. Also, the development of specific protocols for different diseases and conditions, specialized training of therapists, and close cooperation with physicians and other members of the treatment team can increase the quality of the implementation of interventions. Finally, psychosomatic art therapy can be considered as a complementary approach that helps to reconstruct the relationship between the mind and the body by using the capacity for symbolic expression, emotion regulation, physical attention, meaning-making, and active participation. The main value of this approach lies in an integrated view of the human being, which sees illness not merely as a set of physical symptoms nor merely a consequence of psychological problems, but as a complex and multidimensional experience in which the body, emotion, cognition, behavior, and the social environment interact with each other.