Quality of life in children with cancer is a multidimensional concept that is not limited to physical condition, but also includes the emotional, cognitive, social, family, educational, and functional dimensions of the child. Cancer diagnosis and treatment can disrupt many of a child's daily activities and affect a child's sense of independence, social relationships, body image, mood, and participation in age-appropriate activities. From a psycho-oncology perspective, improving the quality of life requires a comprehensive approach that pays attention to the child's psychological and social needs in addition to controlling physical symptoms. Targeted art interventions in this framework can be used as one of the complementary methods to support psychological adjustment and increase the child's participation in daily life. The theoretical basis of these interventions is based on the view that creative activity can provide the ground for the expression of emotion, strengthen the sense of agency, create an experience of success, facilitate communication, and increase social participation. By comprehensively assessing the child's condition, distress severity, stage of illness, type of treatment, physical condition, family circumstances, and individual interests, the psycho-oncologist can determine the goals of art therapy tailored to the child's needs. Painting, painting, collage, making objects, storytelling, music, drama, and other artistic activities can be chosen based on the child's developmental capacity and physical condition. One of the important uses of art interventions is to facilitate the expression of emotions that a child may not be able to express verbally. Fear, anger, sadness, loneliness, worry about the future, and the experience of lack of control can be represented in a visible and conversational way through artistic activity. This process can help the psycho-oncologist better identify the child's emotional needs and design a more appropriate intervention. Art can also play a role in regulating emotion, introducing the child to ways to reduce tension, increase relaxation, and direct difficult emotions. During cancer treatment, experiencing pain, fatigue, nausea, movement limitations, and frequent hospitalizations may reduce a child's sense of independence. Providing the opportunity to choose tools, colors, subjects, and methods of activity can restore some sense of control to the child. This sense of agency can be important in psychological adjustment to the treatment situation. Artistic interventions can also help reconstruct a child's body image, as physical changes caused by illness and treatment may affect a child's perception of the body and identity. Creative activities can provide an opportunity to redefine the body, express feelings about changes in appearance, and foster gradual self-acceptance. On the other hand, art can help keep a child connected to age-appropriate activities and prevent their identity from being limited to the role of a "patient." Creating opportunities for play, creativity, and experience success can strengthen a child's sense of competence and personal identity. In a hospital setting, targeted art interventions can more balanced a child's experience of the treatment environment and create an opportunity for non-medical activity. However, the type and duration of activity should be coordinated with the child's physical condition, energy level, pain, and attention capacity. Short, flexible, and selectable activities may be more appropriate for many children. Art can also be used to foster social connection. Group activities, if the conditions are right, can increase a sense of belonging, participation, and connection with peers, and reduce feelings of isolation caused by hospitalization or absenteeism from school. However, group activities should not be imposed on the child, and their individual preferences and mental state should be taken into account. The family also plays an essential role in improving a child's quality of life, and joint artistic activities can increase the opportunity for positive interaction between the child and the parent. Parents can create shared emotional experiences with the child through participation in creative activities, without constantly focusing on the disease. A psycho-oncologist can guide the family in choosing appropriate activities and creating a supportive environment. Another application of art is to support the child's communication with the treatment team. Some children may be more comfortable talking about their pain, fears, or concerns through an image or art play, and this information can help professionals better understand the patient's experience. In this context, artworks should be used alongside other assessment methods and not as an independent diagnostic tool. Interpreting visual symbols regardless of the child's individual, cultural, and developmental context can lead to misperceptions. Challenges in implementing art interventions include differences in age, stage of development, type of cancer, severity of treatment, and children's individual preferences. The limited research evidence, heterogeneity of art therapy protocols, differences in tools for measuring quality of life, and the limited volume of some studies also make it difficult to interpret the results. In addition, the child's physical condition may reduce the possibility of continuous participation in art activities. Interventions should therefore be flexible, person-centred, and aligned with the medical treatment plan. Art therapy should not replace medical care, pain management, or evidence-based psychological therapies, but should be considered as part of comprehensive, multidisciplinary care. Collaboration between a psycho-onclogist, oncology, psychologist, art therapist, nurse, social worker, and family can allow for the design of more precise interventions. It is suggested that future research investigate the impact of targeted art interventions on various aspects of quality of life, including psychological distress, emotion regulation, body image, social interaction, sense of agency, and daily participation. The use of longitudinal studies and standardized quality of life tools can also help identify the lasting consequences of these interventions. Also, designing programs tailored to different age groups and stages of the disease can increase the effectiveness and clinical applicability. Overall, the role of the psycho-oncologist in the use of targeted art interventions is to create a link between the child's medical needs and the psychosocial experience. Art can provide a space for expression, communication, choice, creativity, and experience success, and help the child maintain a part of his or her identity and routine life activities during treatment. The ultimate goal of this approach is not just to reduce psychological symptoms, but to support a higher quality of life, more active participation, more effective communication, and more sustainable adjustment of the child to the experience of cancer.