Art therapy and the mind-body relationship is based on the view that psychological processes and physical responses do not operate independently, but are in continuous interaction with each other. Stress, anxiety, fear, and persistent emotions can be associated with changes in physiological arousal, heart rate, breathing, muscle tension, and pain perception, and in contrast, physical symptoms and limitations can also affect mood, cognition, and emotion regulation. Art therapy can be used as a complementary intervention to modulate this mind-body interaction by creating a creative and purposeful process. Activities such as painting, drawing, music, working with flowers, and other artistic activities focus a person's attention on the momentary process of experience, body movements, breathing, emotions, and environmental stimuli, and can provide the basis for increasing physical self-awareness. From a psychological perspective, one of the possible mechanisms of art therapy is to reduce rumination and shift attention from threat-oriented thoughts to a structured and meaningful activity. When a person is involved in the process of artistic creation, attention, perception, and motor activity are integrated into a coherent experience, which can help reduce mental confusion and increase a sense of control. On the other hand, creative experience may allow the identification and expression of emotions that are experienced at the physical level in the form of muscle tension, restlessness, or fatigue. In this context, the artwork can act as a mediator between psychological experience and physical experience, leading the individual to observe the relationship between feeling, thought, and bodily reaction. Research evidence in the field of artistic interventions has shown that some artistic activities can be associated with a reduction in psychological distress, anxiety, and stress indicators and an improvement in some indicators of quality of life, although the results of studies are not the same in terms of the intensity of the effect and the type of physical consequences. This suggests that art therapy can be considered as part of a biopsychosocial approach, rather than a substitute for medical treatment. In patients with chronic diseases, cancer, pain, and other physical conditions, the experience of illness usually has both physical and psychological dimensions at the same time, and art therapy can be used with the aim of reducing distress, strengthening adaptation, and increasing the patient's participation in psychological care. For example, the patient can observe changes in breathing, heart rate, muscle tension, or physical sensations without judgment when creating the work, and then examine their relationship with their emotions and thoughts. Such a process can help strengthen physical literacy and increase the ability to detect symptoms of emotional arousal early. In mindfulness-based interventions, some artistic activities can be combined with a focus on the process, sensory experience, and presence in the moment, thereby helping to reduce mental engagement and increase acceptance of experience. In the context of chronic pain, art therapy may play a complementary role by reducing excessive attention to pain, facilitating emotional expression, and strengthening coping strategies; however, it should not be claimed that art activity alone treats the physical cause of pain. One of the important applications of this approach is to help the patient redefine their relationship with the body, especially in situations where illness or treatment has altered body image, reduced physical abilities, or felt alienated from the body. Art can allow for body representation, change perspective on physical limitations, and create new personal narratives about the experience of the disease. In psycho-oncology, this capacity becomes even more important because cancer diagnosis and the treatment process can be associated with anxiety, physical changes, fatigue, pain, sleep disturbances, and anxiety about the future, and artistic interventions can help manage part of this psychological burden. However, the important challenge in this area is to distinguish the psychological effects of art therapy from direct physical changes and medical factors. Also, differences in the type of disease, severity of symptoms, type of artistic media, duration of intervention, and individual characteristics of patients make the results of the studies not easily generalizable. Another limitation is that many studies focus on self-reported indicators such as anxiety, stress, and quality of life, and direct measurement of physiological changes has not been done in all studies. Therefore, it is suggested that future studies use objective indicators such as heart rate, heart rate variability, breathing patterns, and other physiological markers along with psychological scales to examine the mind-body interaction more accurately. Also, designing person-centered interventions and combining art therapy with mindfulness, emotion regulation, cognitive-behavioral therapy, and physical rehabilitation can provide the ground for investigating the multidimensional effects of this approach. Overall, art therapy, as a complementary intervention, can strengthen the link between psychological experience and physical awareness and help the individual to better adapt to the physical condition by reducing distress, increasing self-awareness, regulating emotion, and strengthening the sense of control.